BY Ben Makeham May 8, 2020
The gastrointestinal system is home to 70% of the body’s immune cells.
The gut microbiota and its metabolites, particularly short chain fatty acids such as butyrate, interact with the intestinal epithelial cells and the underlying immune cells.
As a result, bacteria-derived metabolites are thought to trigger a cascade of changes in immune cell phenotypes and cytokine secretion which supports enhanced immune function.
A healthy gut microbiota and various strains of probiotics enhance immune system function via various different pathways, and have been observed to:
Induce and activate dendritic cells and macrophages
Directly activate natural killer T cells
Increase IgA production by B-cells
Specific probiotic strains may therefore have the ability to influence the activity of both innate and adaptive immune cells in the gastrointestinal system, altering systemic immune function when immune cells enter circulation and travel across the body. Strains with clinically proven immune enhancing effects include Lactobacillus rhamnosus GG, Lactobacillus plantarum HEAL 9 and Lactobacillus paracasei 8700:2, found across our Biome DailyTM, Biome Daily KidsTM and Biome AdvancedTM Probiotics. Find out more about our probiotics for clinically proven immune protection here (download button, link etc.)